Comparative Clinical and Immunological Characteristics of Seripositive And Seronegative Rheumathoid Arthritis
DOI:
https://doi.org/10.55640/ijmm-05-04-02Keywords:
Rheumathoid factor, rheumatoid arthritis, anti-CCPAbstract
To study and compare the diversity and specific characteristics of the clinical course of seronegative and seropositive Rheum factor, anti-CCP positive, and anti-CCP negative variants of rheumatoid arthritis.
Methods: Information was collected from studies measuring visual analog scale (VAS) pain, disease activity score 28 (DAS28), X-ray of joints, tender joint count (TJC), swollen joint count (SJC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP).
Results: The study included 80 patients with rheumatoid arthritis divided into two equal groups: seropositive and seronegative RA. The mean age was comparable between groups (36.87± years in Group I vs. 37.65± years in Group II), with a clear predominance of female patients in both groups (80% and 90%, respectively). Articular involvement was the most common clinical form; however, systemic (articular-visceral) manifestations were more frequent in the seronegative group (47.5% vs. 35%). Anti-CCP positivity was significantly higher in the seronegative group (67%) compared to the seropositive group (27%). Disease activity analysis revealed that moderate activity predominated in the seropositive group (55%), whereas high disease activity was more common in the seronegative group (57.5%). Regarding disease staging, the established (advanced) stage was the most frequent in both groups (55% in Group I and 60% in Group II), while very early stages were rare or absent.
Downloads
References
Nagpal S., Na S., Rathnachalam R. Noncalcemic actions of vitamin D receptor ligands. Endocr Rev 2005;26:662–87.
Mathieu C., Adorini L. The coming of age of 1,25-dihydroxyvitamin D(3) analogs as immunomodulatory agents. Trends Mol Med 2002;8:174–9.
Lemire J. Vitamin D3, autoimmunity and immunosuppression. In: Vitamin D. 2nd ed. (D. Feldman, J. W. Pike, and F. Glorieux, eds). San Diego: Elsevier Academic Press, 2005:1753–62.
Lemire J.M., Archer D.C., Beck L., Spiegelberg H.L. Immunosuppressive actions of 1,25-dihydroxyvitamin D3, preferential inhibition of Th1 functions. J Nutr 1995;125:1704–8.
Boonstra A., Barrat F.J., Crain C. et al. 1alpha,25-dihydroxyvitamin D3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J Immunol 2001;167:4974–80.
Cutolo M. Vitamin D and autoimmune rheumatic diseases. Rheumatology 2009;48:210–2. 7. Hewison M., Adams J.S. Extra-renal 1αhydroxylase activity and human disease. In: Vitamin D, 2nd ed. (D. Feldman, J. W. Pike).
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Turaev Ikhtyor (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
