Modulation of Oxidative Stress by Glycine in Experimental Myocardial Infarction
DOI:
https://doi.org/10.55640/ijmm-05-03-02Keywords:
Glycine, antioxidant system, superoxide dismutaseAbstract
Glycine reduces oxidative stress and limits lipid peroxidation during experimental myocardial infarction in rabbits. Administration of glycine at a dose of 100 mg/kg delayed the early increase in malondialdehyde and significantly lowered plasma levels of malondialdehyde and conjugated dienes throughout 3–72 hours post-coronary occlusion. This effect was accompanied by higher activities of key antioxidant enzymes, superoxide dismutase and catalase, indicating enhanced endogenous antioxidant defense. These results suggest that glycine exerts cardioprotective effects through its antioxidant and anti-stressor properties and may serve as a potential therapeutic agent for reducing oxidative damage during ischemic heart injury.
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Copyright (c) 2026 Yuldashev Nosirdjan Muhamedjanovich, Rashidova Durdona Akhad kizi, Umarkhujaeva Iroda Zukhriddin kizi (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
