Analysis Of The Frequency Of Detection And Clinical Manifestations Of Cystic Fibrosis In Children
DOI:
https://doi.org/10.55640/ijmm-05-01-05Keywords:
Cystic fibrosis, sweat test, children, coughAbstract
Objective of the study. To investigate the frequency of detection and the characteristics of clinical manifestations of cystic fibrosis in children. Materials and methods. A total of 106 patients with cystic fibrosis aged from 0 months to 14 years were observed. All patients were hospitalized and treated in the departments of pulmonology, early childhood pathology, and gastroenterology. Results. In children with cystic fibrosis, the main clinical symptoms of the bronchopulmonary system were cough, dyspnea, oral rales, lethargy, and loss of appetite. Upon admission to the hospital, the general condition of most patients was assessed as severe. Conclusion. The high frequency of repeated hospitalizations and early mortality caused by severe respiratory complications indicate the need to improve programs for early detection, long-term follow-up, and multidisciplinary management of children with cystic fibrosis.
Downloads
References
Voronkova A.Yu., Amelina E.L., Kashirskaya N.Yu., Kondratyeva E.I., Krasovsky S.A., Starinova M.A., Kapranov N.I. /Register of patients with cystic fibrosis in the Russian Federation. - M.: ID "MEDPRAKTIKA-M", 2019.-68p.
Geppe N.A., Rozinova N.N., Volkov I.K., Mizernitsky Yu.L. Working classification of the main clinical forms of bronchopulmonary diseases in children//Trudny patsient. -2009. -Volume 7. -No.1-2. -P.35-40.
Kachiyan M.M. Clinical and genetic characteristics of children and adolescents with cystic fibrosis in the Krasnodar region and assessment of the role of staphylococcal infection in cystic fibrosis 2021.-140p.
Kondratyeva E.I., Krasovsky S.A., Voronkova A.Yu., Amelina E.L., Chernyak A.V., Kashirskaya N.Yu. Register of patients with cystic fibrosis in the Russian Federation. //M.: "Medpraktika-M", 2017. P. 70.
Simonova O.I. et al., Cystic Fibrosis: a guide for doctors Moscow: Pediatr, 2018. - 84 p.
Skudarnov E.V., Dorokhov N.A., Malyuga O.M., Seroklinov V.M. "Social and genetic aspects of community-acquired pneumonia in children"//Pediatricheskiy vestnik Yuzhnogo Urala. --2017.--No.1.-- P.67-70.
Shaginyan I.A., Avetisyan L.R., Chernukha M.Yu., Siyanova E.A., Burmistrov E.M., Voronkova A.Yu. et al. Epidemiological significance of molecular variability of the genome of Pseudomonas aeruginosa isolates causing chronic lung infection in patients with cystic fibrosis. //Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya. 2019;21(4):340--351.
Yashin S.S., Yunusova Yu.R., Isakova N.V., Serdobolskaya Yu.V. CYSTIC FIBROSIS (MUCOVISCIDOSIS) // Sovremennye problemy nauki i obrazovaniya. -- 2022. -- No. 5. P. 236-247.
Caverly L.J., LiPuma J.J. /Cystic fibrosis respiratory microbiota: unraveling complexity to inform clinical practice. // Expert Review of Respiratory Medicine. 2018;12 (10): 857-865.
Middleton P.G., Taylor-Cousar J.L. Development of Elexacaftor -- Tezacaftor -- Ivacaftor: Highly Effective CFTR Modulation for the Majority of People with Cystic Fibrosis//Expert Rev Respir Med. 2021;15(6):723--735.
Paterson S.L., Barry P.J., Horsley A.R. Tezacaftor and Ivacaftor for the Treatment of Cystic Fibrosis//Expert Rev Respir Med. 2020;14(1):15--30.
12. Uzakova, Sh.B., Inomov, B.N., & Abdullaeva, M.K. (2024). Analysis of clinical manifestations and laboratory parameters of cystic fibrosis in children. Bulletin of the Tashkent Medical Academy, 1, 149-151.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Shamsiev F.M., Uzakova Sh.B., Inomov B.N., Azizova N.D., Abdullaeva M.K., Karimova M.Kh. (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
