The leading pathogenetic mechanisms of stress development are associated with deterioration of human functional state, subsequent decrease in work performance, and disease development. The relevance of studying immobilization stress and using the ELI-Neuro-Test is driven by the need to understand the mechanisms of organism adaptation to extreme exposures and to diagnose early pathological changes. The most promising markers for identifying changes associated with chronic immobilization stress are antibodies to NF-200 and antibodies to the voltage-gated calcium channel (V-GCC). These assessment criteria will be more informative when included in a multifactorial diagnostic panel.

Immobilization stress, ELI-Neuro-Test, adaptation of the organism

Wohleb, E.S. Integrating neuroimmune systems in the neurobiology of depression / E.S. Wohleb, T. Franklin, M. Iwata, R.S. Duman // Nat Rev Neurosci. - 2016. -Vol. 17, № 8. - P. 497-511.

Sarjan, H.N. Chronic stress induced duration dependent alterations in immune system and their reversibility in rats / H.N. Sarjan, H.N. Yajurvedi // Immunol Lett. -2018. - Vol. 197. - P. 31-43.

Takahashi, A. Aggression, social stress, and the immune system in humans and animal models / A. Takahashi, M.E. Flanigan, B.S. McEwen, S.J. Russo // Front Behav Neurosci. - 2018. - Vol. 12. - P. 1-16.

Zagurovsky, V.M. Stress and its consequences (prehospital and early hospital stages) / V.M. Zagurovsky // Emergency Medicine. -2014. - № 7(62). - P. 11-23.

Torgashov, M.N. Some pathogenetic mechanisms of stress-induced pathology development / M.N. Torgashov, V.S. Myakotnykh // Bulletin of Ural Medical Academic Science. - 2016. - № 2. - P. 64-74.

Korneva, E.A. Cellular-molecular bases of neuroimmune interaction changes under stress / E.A. Korneva, S.N. Shanin, N.S. Novikova, V.A. Pugach // Russian Physiological Journal named after I.M. Sechenov. - 2017. - Vol. 103, №3,-P. 217-229.

Deak, T. A multispecies approach for understanding neuroimmune mechanisms of stress / T. Deak, A. Kudinova, D.F. Lovelock, B.E. Gibb, M.B. Hennessy // Dialogues Clin Neurosci. - 2017. - Vol. 19, № 1. - P. 37-53.

Lutsky, I.S. Influence of chronic psycho-emotional stress on the formation of endothelial dysfunction, vascular remodeling processes, and reduction of cerebral blood flow // Kuban Scientific Medical Bulletin. 2015. №. 3, p. 12-17.

Iriskulov B.U., Azimova S.B., Salihova Yu.B. Pathogenetic and protective aspects of immobilization stress// Journal The Bioscan, 2025, 20(4): p. 180-188.