Changes in Biochemical Indicators During Alcoholic Intoxication
DOI:
https://doi.org/10.55640/ijmm-05-04-05Keywords:
Ethanol, ALT, biochemical indicatorsAbstract
This study dynamically investigated the biochemical and physiological indicators of liver function and the overall metabolic state in rats under conditions of chronic ethanol intoxication. During the experiment, we assessed the activity of liver damage-indicating enzymes in the blood serum - ALT, AST, GGT, and alkaline phosphatase - as well as changes in the levels of albumin, total protein, glucose, triglycerides, and cholesterol. The results showed that chronic ethanol intoxication disrupts the structural-functional integrity of hepatocytes, leading to cytolysis, cholestasis, disorders of lipid and carbohydrate metabolism, and a decrease in the synthetic function of the liver. Furthermore, a decrease in body weight and an increase in the liver index in the experimental animals confirmed the escalating hepatotoxic effect of ethanol.
Downloads
References
Kwo P.Y., Cohen S.M., Lim J.K. ACG Clinical Guideline: evaluation of abnormal liver chemistries // The American Journal of Gastroenterology. - 2017. - Vol. 112, No. 1. - P. 18-35.
Osna N.A., Donohue T.M., Kharbanda K.K. Alcoholic liver disease: pathogenesis and current management // Alcohol Research: Current Reviews. - 2021. - Vol. 41, No. 1. - P. 1-15.
Louvet A., Mathurin P. Alcoholic liver disease: mechanisms of injury and targeted treatment // Nature Reviews Gastroenterology & Hepatology. - 2021. - Vol. 18, No. 5. - P. 231-242.
McGill M.R. The past and present of serum aminotransferases in liver injury // Journal of Clinical and Translational Research. - 2022. - Vol. 8, No. 2. - P. 121-130.
European Association for the Study of the Liver (EASL). Clinical practice guidelines on liver diseases // Journal of Hepatology. - 2022. - Vol. 77, No. 2. - P. 528-562.
O'Shea R.S., Dasarathy S., McCullough A.J. Alcoholic liver disease update // Hepatology. - 2020. - Vol. 71, No. 1. - P. 306-333.
Arab J.P., Arrese M., Trauner M. Recent insights into the pathogenesis of nonalcoholic fatty liver disease // Annual Review of Pathology: Mechanisms of Disease. - 2021. - Vol. 16. - P. 321-350.
Bellentani S., Marino M. Epidemiology and natural history of fatty liver disease // Annals of Hepatology. - 2020. - Vol. 19, No. 6. - P. 579-584.
Seitz H.K., Bataller R., Cortez-Pinto H. et al. Alcoholic liver disease // Nature Reviews Disease Primers. - 2021. - Vol. 7, No. 1. - Article 16.
Manthey H.D., Beier J.I., Arteel G.E. Alcoholic liver disease and lipid metabolism // Hepatology Communications. - 2020. - Vol. 4, No. 8. - P. 1159-1171.
Shimano H., Sato R. SREBP-regulated lipid metabolism: converging pathways in hepatic steatosis and dyslipidemia // Nature Reviews Endocrinology. - 2021. - Vol. 17, No. 12. - P. 710-722.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Akhrorkhonova Muslima Zohid qizi, Abdullayeva Mashhura Ikromjonovna, Babadjanova Shoira Agzamovna (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
